Lactoferrin Cas number:146897-68-9 Molecular Formula:C141H224N46O29S3
Melting Point | 222-224°C |
Density | 1.48±0.1 g/cm3(Predicted) |
storage temp | Inert atmosphere,Room Temperature 2-8°C |
solubility | H2O: 1 mg/mL |
optical activity | N/A |
Appearance | Pink Powder |
Purity | ≥98% |
Lactoferrin, a granule-associated glycoprotein, is a cationic protein with a high proportion of arginine and lysine at the N-terminal region, with two glycosylation and several iron-binding sites. Lactoferrin is highly antibacterial against both gram-positive and gram-negative bacteria at concentrations ranging from 3 to 50 μg/ml. It is believed that these lethal effects are due to a direct interaction of lactoferrin with the cell surface and subsequent disruption of normal permeability functions of the membrane, a so-called dissipation of proton motive force action . Similarly, expression of an antimicrobial tachyplesin gene from Asian horseshoe crabs led to antibacterial activity against Erwinia spp. in transgenic potato .
Lactoferrin was used in the fractionation of lactoperoxidase and lactoferrin from bovine whey using a cation exchange membrane. It was used in the determination of lactoferrin and immunoglobulin G in animal milks by new immunosensors.