Metformin, an organic compound with the chemical formula of C4H11N5, is a first-line drug for the treatment of type 2 diabetes, especially for overweight patients.

In 2019, Cancer Cell recently published an article in which researchers found that the use of metformin during fasting significantly inhibited tumor growth and proposed PP2A-GSK3 β- The MCL-1 pathway may be a new target for tumor therapy. Research has found that tumor cells exhibit metabolic changes that are different from normal cells, and tumor cells themselves can adapt to changes in the metabolic environment through the conversion between glycolysis and oxidative phosphorylation (OXPHOS).

Indications

(1) Metformin tablets were first used for type 2 diabetes patients, especially obese type 2 diabetes patients, whose diet control and physical exercise were ineffective.

(2) This product can be used in combination with insulin to reduce insulin usage and prevent hypoglycemia.

(3) It can be combined with sulfonylurea hypoglycemic drugs and has synergistic effects.

Adverse reaction editing and broadcasting

(1) Occasionally experiencing nausea, vomiting, diarrhea, abdominal pain, bloating, indigestion, fatigue, etc.

(2) Occasionally experiencing fatigue, weight loss, headache, dizziness, abnormal taste, rash, chills, flu like symptoms, palpitations, flushing, and other symptoms.

(3) Rare lactic acidosis, characterized by vomiting, abdominal pain, excessive ventilation, and consciousness disorders.

Contraindications

It is forbidden for people who are allergic to this product, diabetes ketoacidosis, liver and kidney dysfunction (serum creatinine exceeds 1.5mg/dL), pulmonary dysfunction, heart failure, acute myocardial infarction, severe infection and trauma, major surgery and clinical hypotension and hypoxia, alcoholism, vitamin B12, folic acid deficiency, people with severe diabetes nephropathy, diabetes fundus disease, pregnant and lactating women.

Precautions

(1) Patients with a history of lactic acid poisoning and elderly patients should use it with caution. Due to the potential for lactic acid poisoning due to the accumulation of this product, it can be life-threatening. Therefore, renal function should be monitored and the minimum effective dose should be given to reduce the risk of lactic acid poisoning.

(2) During stress states such as fever, coma, and infection, during surgical procedures and the use of iodine containing contrast agents for examination, the use of this product should be temporarily stopped, as it may lead to acute deterioration of renal function.

(3) When combined with sulfonylurea drugs and insulin, this product can cause hypoglycemia. When taking this product, it is advisable to avoid drinking alcohol as much as possible. Easy to cause hypoglycemia or lactic acid poisoning. Patients with liver dysfunction should use it with caution.

(4) This product can interfere with the absorption of vitamin B12. It is recommended to monitor the blood count.