Orlistat Cas number:132539-06-1 Molecular Formula: C28H29NO
| Melting Point | 195-200°C |
| Density | 1.4 g/cm³ |
| storage temp | 2-8℃ |
| solubility | insoluble in water, slightly soluble in ethanol, easily soluble in chloroform and methanol |
| optical activity | +71.6 (c=1.0, ethanol) |
| Appearance | white or off-white crystalline powder |
Olistat is a long-lasting, specific gastrointestinal lipase inhibitor that can prevent the hydrolysis of triglycerides into absorbable free fatty acids and monoacylglycerols, preventing them from being absorbed, thereby reducing calorie intake and controlling weight. When used as an over-the-counter medication for self medication, orlistat is suitable for the treatment of obese or overweight patients (with a body mass index of ≥ 24 and an approximate calculation of weight/height 2).
Orlistat is a weight loss drug, marketed as Xenical.
Olistat is a saturated derivative of lipstatin. Lipstatin is an effective natural pancrelipase inhibitor isolated from Streptomyces toxitricini It mainly acts on the gastrointestinal tract. It can inhibit the enzymes needed by the gastrointestinal tract to digest fat, including pancreatic ester and gastric ester, and reduce the absorption of gastrointestinal ester to fat to help lose weight, but it still needs to be combined with exercise and diet to lose weight.
The recommended dosage for Olistat capsules is 0.12g capsules taken with meals or within one hour after meals. If there is a meal that has not been eaten or if the food does not contain fat, one medication can be omitted. The therapeutic effect of long-term use of orlistat capsules, including weight control and improvement of risk factors, can be sustained. The patient's diet should be nutritionally balanced, with slightly low calorie intake. Approximately 30% of the calorie intake comes from fat, and the food should be rich in fruits and vegetables.
